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IN THIS ISSUE:
January 2008

Treating Behavioral Problems in Dementia
No drug is clearly efficacious for behavioral problems in dementia, and all are associated with significant risks.

Prolactin Elevation and Antipsychotics
Risperidone (Risperdal) seems to increase prolactin more than conventional and other second-generation antipsychotics; adjunctive aripiprazole (Abilify) may lower antipsychotic-induced hyperprolactinemia.

In Brief
Atomoxetine Effective for ADHD in Preschool Children; Excessive Body Weight Increases Risk of Dementia

Treating Adolescent Mania
Olanzapine (Zyprexa) effectively treats adolescent bipolar disorder but appears to cause harmful medical consequences in young patients.

Isotretinoin and Depression
Depression is a possible side effect of treatment with isotretinoin (Accutane and others).

Prolactin Elevation and Antipsychotics

January 2008

Because of their strong blockade of dopamine D2 receptors, conventional antipsychotics increase prolactin release from the pituitary and can cause hyperprolactinemia. Elevated prolactin may lead to gynecomastia, galactorrhea, decreased fertility, menstrual irregularities, sexual dysfunction,…

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