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IN THIS ISSUE:
December 2007

Index, Volume 30, 2007

High-Dose Ziprasidone
Patients with treatment-resistant psychosis may benefit from higher-than-recommended doses of ziprasidone (Geodon).

Baby Steps
Our clinical knowledge in psychiatry has increased over the past year, but scientific understanding and intervention technology still leaves much to be desired.

High Doses of Venlafaxine
Higher doses of venlafaxine (Effexor and others) likely increase the chance of antidepressant response, but also increase the risk of side effects.

SSRIs and Bleeding Risk in Patients with Hepatitis C
The risk of selective serotonin reuptake inhibitors causing bleeding in patients with hepatitis C is modest.

Bupropion versus SSRIs for Anxiety in MDD
According to Papakostas and colleagues, bupropion (Wellbutrin and others) appears to work as well as selective serotonin reuptake inhibitors to treat anxiety in patients with major depressive disorder.

Torsades de Pointes with Haloperidol
Intravenous administration of haloperidol (Haldol and others), especially at high doses, can cause QT prolongation and torsades de pointes.

In Brief
Ziprasidone for borderline personality disorder: A negative trial; Adjunctive medications for weight loss in patients with schizophrenia or bipolar disorder

Index, Volume 30, 2007

December 2007

Acupuncture, 5

Alternative medicine, 3, 23

Alzheimer's disease, 1, 31, 37

Amisulpiride, 29

Antidepressants

- drug interactions, 7, 42

- effect on enzymes, 30

- genetics, 1-2

- hyponatremia, 24

- in pregnancy, 45

- rapidly acting, 4

- suicide, 19, 34, 37

- stroke, 38

Antipsychotics, 7, 21-22

- for Alzheimer's disease, 1

- bone mineral density, 45

- in dementia, 39-40

- and diabetes, 2, 11

- and myocardial infarction, 8

- switching, 43

Anxiety, 15, 22, 28, 48

Aripiprazole (Abilify), 12, 29, 32

Atomoxetine (Strattera), 32

Attention deficit hyperactivity disorder (ADHD), 10, 13-14

Bipolar disorder, 31, 45

- cardiovascular effects, 11

- depression, 10-11, 35-36, 41-42, 49

- mania, 15-16

- omega-3 fatty acids, 3

- polycystic ovarian syndrome (PCOS), 7

- weight gain, 49

Bleeding, 47-48

Bone mineral density (BMD), 40, 45

Borderline personality disorder, 49

Buprenorphine (Suboxone and others), 29-30

Bupropion (Wellbutrin and others), 10-11, 35-36, 39, 48

Carbamazepine (Tegretol and others), 15-16, 32

Cardiac effects, 8, 11, 15, 29-30, 49

Celecoxib (Celebrex), 26

Citalopram (Celexa and others), 18, 27-28

Children and adolescents, 13-14, 19, 33, 44

Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE), 1, 50

Clozapine (Clozaril and others), 3, 7, 12, 29, 43-44

Cognitive behavioral therapy (CBT), 23

Cognitive impairment, 5, 33

Coronary artery disease, 18

COX-2 inhibitors, 26

Cytochrome P450 2D6 enzyme, 30

Deep brain stimulation (DBS), 6

Dementia, 29, 39-40

Depression, 31, 41, 44

- acupuncture, 5

- and anxiety, 48

- atomoxetine, 32

- bone mineral density, 40

- bupropion, 39

- in cardiac patients, 18

- duloxetine, 17

- in pregnancy, 36-38, 45

- psychotic, 25-26

- rapidly acting, 4

- riluzole, 22

- selective serotonin reuptake inhibitors, 17-18

- after stroke, 38

- suicide, 34, 37

- and taste, 15

- treatment-resistant, 3, 21, 27-28

Desipramine (Norpramin and others), 10-11

Diabetes, 2, 11

Donepezil (Aricept), 24

Dosing, 17, 17-18, 19-20, 47, 50

Drug interactions, 3, 7, 32, 42

Duloxetine (Cymbalta), 17, 24, 28, 30

Elderly, 21-22, 23, 39-40

Electroconvulsive therapy (ECT), 21, 41

Erectile dysfunction, 6

Escitalopram (Lexapro), 24, 30

Fluoxetine (Prozac and others), 30

Fractures, 21-22

Galantamine (Razadyne), 5

Generalized anxiety disorder (GAD), 28

Genetic polymorphisms, 1-2

Haloperidol (Haldol and others), 49

Hepatitis C, 47-48

Heroin, 29-30

Hyperprolactinemia, 25, 33

Hypertension, 11

Hypnotics, 23

Hyponatremia, 24

Insomnia, 3, 23

Interferon (Intron A, Infergen, or Pegasys), 47-48

Ketamine, 4

Korsakoff's psychosis, 14-15

Lamotrigine (Lamictal), 3, 35-36

Linezolid (Zyvox), 19

Lithium, 27-28, 31

Methadone (Dolophine), 15, 24, 29-30, 32

Methylphenidate (Ritalin and others), 13-14

- transdermal (Daytrana), 10

Mifepristone (Mifeprex), 25-26

Migraines, 42

Mirtazapine (Remeron and others), 27-28

Modafinil (Provigil), 41-42

Monoamine oxidase inhibitors (MAOIs), 7, 19

Myocardial infarction, 8

Naltrexone (Depade), 29-30

Natural remedies, 23

N-methyl-D-aspartate (NMDA), 4

Nonsteroidal anti-inflammatory drugs (NSAIDs), 26

Nortriptyline (Pamelor and others), 27-28

Noradrenaline reuptake inhibitors, 15

Obesity, 20

Obsessive compulsive disorder (OCD), 6

Olanzapine (Zyprexa), 13, 15-16, 45-46, 49

Omega-3 fatty acids, 3, 41

Opioid addiction, 24

Osteoporosis, 21-22, 40

Pain, 15, 19, 24

Paliperidone (Invega), 7, 13

Parkinson's disease, 7, 29

Paroxetine (Paxil and others), 10-11, 15, 30, 35-36, 36-38

Pedophilia, 33

Pervasive developmental disorders, 33

Polycystic ovarian syndrome (PCOS), 7

Prazosin (Minipress and others), 35

Pregabalin (Lyrica), 28

Pregnancy, 36-38, 45

Prolactin, 25, 33, 45

Posttraumatic stress disorder (PTSD), 35

QTc prolongation, 29-30, 49

Quetiapine (Seroquel and others), 29, 32

Rasagiline (Azilect), 7

Reboxetine, 15

Repetitive transcranial magnetic stimulation (rTMS), 21

Riluzole (Rilutek), 22

Risperidone (Risperdal), 3, 7, 12, 25, 33

- long-acting injection (Risperdal Consta), 19-20, 24

Rivastigmine (Exelon), 37

Self-harm, 41

Schizophrenia, 12, 15, 45, 45-46, 50

- cardiovascular disease, 8

- celecoxib, 26

- cognitive impairment, 5

- paliperidone, 13

- risperidone, long-acting, 19-20

- switching antipsychotics, 43-44

- treatment-resistant, 7, 29

- violent behavior, 16

- weight gain, 49

Selective serotonin reuptake inhibitors (SSRIs)

- anxiety, 48

- with atomoxetine, 32

- bleeding, 47-48

- bone mineral density, 40, 45

- children and adolescents, 44

- dosing, 17-18

- fracture risk, 21-22

- hyponatremia, 24

- metabolic effects, 20

- with triiodothyronine, 31

Sequenced Alternatives to Relieve Depression (STAR*D), 27-28, 50

Serotonin syndrome, 19

Sertraline (Zoloft and others), 10-11, 18, 30, 32

Sexual dysfunction, 6

Sildenafil (Viagra), 6

Smoking cessation, 9, 44-45

Stroke, 11, 38

Substance abuse, 16

Suicide, 19, 34, 37, 41

Sulpiride, 29

Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), 36, 50

Taste, 15

Teratogenesis, 36-38

Thiamine deficiency, 14-15

Topiramate (Topamax), 15-16, 33, 49

Torsades de pointes, 49

Tranylcypromine (Parnate), 27-28, 35-36

Triptans, 42

Triiodothyronine (T3), 27-28, 31

Vagus nerve stimulation (VNS), 3

Valproate (Depakote), 7

Vardenafil (Levitra), 6

Varenicline (Chantix), 9, 44-45

Venlafaxine (Effexor and others), 19, 27-28, 28

- bipolar depression, 10-11, 36

- dosing, 47

Violent behavior, 16

Weight gain, 20, 45-46, 49

Weight loss, 33

Wernicke-Korsakoff syndrome, 14-15

Wernicke's encephalopathy, 14-15

Ziprasidone (Geodon), 8, 29, 49, 50

Zonisamide (Zonegran), 49

Zopiclone, 23