Patients with treatment-resistant psychosis may benefit from higher-than-recommended doses of ziprasidone (Geodon).
Our clinical knowledge in psychiatry has increased over the past year, but scientific understanding and intervention technology still leaves much to be desired.
High Doses of Venlafaxine
Higher doses of venlafaxine (Effexor and others) likely increase the chance of antidepressant response, but also increase the risk of side effects.
SSRIs and Bleeding Risk in Patients with Hepatitis C
The risk of selective serotonin reuptake inhibitors causing bleeding in patients with hepatitis C is modest.
Bupropion versus SSRIs for Anxiety in MDD
According to Papakostas and colleagues, bupropion (Wellbutrin and others) appears to work as well as selective serotonin reuptake inhibitors to treat anxiety in patients with major depressive disorder.
Torsades de Pointes with Haloperidol
Intravenous administration of haloperidol (Haldol and others), especially at high doses, can cause QT prolongation and torsades de pointes.
Ziprasidone for borderline personality disorder: A negative trial; Adjunctive medications for weight loss in patients with schizophrenia or bipolar disorder
One of the newer second-generation antipsychotics, ziprasidone (Geodon) carries a maximum recommended dosage of 160 mg/day. Evidence suggests that higher doses, at least up to 200 mg/day in clinical trials, bring greater efficacy.
Deutschman and Deutschman have prescribed ziprasidone for patients…