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IN THIS ISSUE:
September 2007

Antidepressants Can Help Prevent Depression after Stroke
Antidepressant drugs may provide relief for many patients suffering from depression following stroke.

Prazosin for PTSD Nightmares
Adjunctive treatment with the α1-blocker prazosin (Minipress and others) reduces trauma nightmares and sleep disturbance in patients with posttraumatic stress disorder.

Treating Bipolar Depression
Antidepressants add little benefit in treating bipolar depression, but the risk of inducing mania appears small.

Are SSRIs Teratogens?
There is a small risk of congenital malformations with fetal exposure to selective serotonin reuptake inhibitors, particularly paroxetine (Paxil and others), during the first trimester.

In Brief
Benefits of Antidepressants versus Suicide Risk; Rivastigmine Does Not Slow Progression to Alzheimer's Disease

Prazosin for PTSD Nightmares

September 2007



Symptoms of posttraumatic stress disorder (PTSD) typically last for decades. Modern antidepressants, most commonly selective serotonin reuptake inhibitors (SSRIs), produce remission in roughly one-quarter to one-half of civilians with PTSD. Response rates in combat veterans tend to be much…

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