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July 2007

New Studies on GAD
Pregabalin and duloxetine (Cymbalta) may be efficacious for adults and venlafaxine (Effexor) for children with generalized anxiety disorder.

Methadone Prolongs QTc Interval
Long-term, high-dose methadone treatment is linked to prolonged QTc intervals.

In Brief
Augmentation for Clozapine Nonresponders; Quetiapine Ineffective for Psychosis/Agitation in Dementia

As Depression Becomes More Treatment-Resistant…
For patients who do not respond to initial antidepressant therapy, augmentation, or switch strategies, further augmentation or switching with different agents can bring about remission—but at a lower rate.

Effects of Antidepressants on 2D6 Enzymes
Duloxetine (Cymbalta) has substantial and escitalopram (Lexapro) and sertraline (Zoloft and others) more modest inhibiting effects on CYP 2D6.

Effects of Antidepressants on 2D6 Enzymes

July 2007

Many drugs of varying categories are broken down by the 2D6 isoform of the cytochrome P450 (CYP) enzyme system in preparation for elimination from the body. Administering other drugs that inhibit CYP 2D6 activity elevates levels of drugs that rely on 2D6 for their metabolism. Preskorn and others studied…

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