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IN THIS MONTH'S ISSUE:
September 2014

Inhaled Loxapine
An inhalation powder formulation of loxapine (Adasuve) has been approved by the FDA to treat acute agitation resulting from schizophrenia or bipolar I disorder in adults.

Lithium in the Elderly
Elderly patients taking low doses of lithium to attenuate the course of Alzheimer disease experience more overall adverse effects than placebo-treated patients, most notably weight gain, diabetes mellitus, and cardiac arrhythmia.

Antipsychotic-Induced Weight Gain and Other Adverse Metabolic Effects: Purported Antidotes
When switching agents is not feasible and diet and exercise are ineffective, current evidence points to metformin (Glucophage and others) as the best antidote for antipsychotic-induced weight gain.

In Brief
Venlafaxine Recall Due to Dissolution Failure; Interventions to Reduce Smoking Are Associated with Decreases in Suicide Risk

SSRIs and QT Prolongation
A recent meta-analysis found varying degrees of QT interval prolongation among selective serotonin reuptake inhibitors (SSRIs).

About the Editorial Advisory Committee

Editorial Advisory Committee:
Ross J. Baldessarini, M.D.
Joseph Biederman, M.D.
Rubin Bressler, M.D.
Andrew W. Brotman, M.D.
Ned Cassem, M.D.
Harold J. DeMonaco, M.S., R.Ph.
Susan R. Donaldson, M.D.
William E. Falk, M.D.
John Greist, M.D.
James W. Jefferson, M.D.
David Katzelnick, M.D.
Samuel J. Keith, M.D.
Martin B. Keller, M.D.
John Racy, M.D.
Eric M. Reiman, M.D.
Jerrold F. Rosenbaum, M.D.
A. John Rush, M.D.
Alan F. Schatzberg, M.D.
Nina R. Schooler, Ph.D.
Michael E. Thase, M.D.
Joanne Doller Wojcik, R.N., M.S.

Editor
Alan J. Gelenberg, M.D.

Assistant Editor
Heather S. Hopkins

Managing Editor
Amy Boynton