Antipsychotics, Antidepressants, Torsades de Pointes, and the Risk of Sudden Death
Some antipsychotics and antidepressants may elevate the risk of sudden death by prolonging the QT interval, especially in older patients and those with heart disease.
Pregabalin in Pregnancy
In one study of human exposure during pregnancy, pregabalin (Lyrica) was associated with an increased rate of congenital malformations.
Preventing MDD via the Web
For people with subthreshold depression, web-based, guided self-help strategies may decrease the risk of developing major depressive disorder.
Escitalopram (Lexapro) Does Not Improve Clinical Outcome in Patients with Heart Failure and Depression; E-cigarette Use in Adolescents Is Associated with Increased Cigarette Smoking in Transition to Adulthood
Cataract Risk and Antipsychotics
In a nested case-control study, investigators found that neither first- nor second-generation antipsychotics were associated with the development of cataracts in patients with schizophrenia.
Antidepressants and Hyponatremia
Almost all antidepressants are associated with hyponatremia, and older patients are at greater risk.
About Alan J. Gelenberg, M.D.
Alan J. Gelenberg, M.D. is a Professor Emeritus at the University of Arizona and has chaired Departments of Psychiatry at Arizona and Penn State. He has also been on the faculty of Harvard Medical School, MIT, and the University of Wisconsin. He is Editor-in-Chief of the Journal of Clinical Psychiatry, the field's most widely read peer-reviewed journal, and founding author of Biological Therapies in Psychiatry Newsletter.
Dr. Gelenberg has been lead author of manuscripts in the Lancet, New England Journal of Medicine, and Journal of the AMA and has published over 280 scientific articles, editorials, and book chapters. He chaired the American Psychiatric Association's (APA) workgroup on Treatment Guidelines for Major Depressive Disorder, 3rd edition, was on a joint APA/AMA taskforce on similar guidelines for primary care and a committee to advise the U.S. Centers for Disease Control about depression. He helped create the ASEX scale to monitor sexual side effects of antidepressants and electronic versions of suicide-assessment instruments.
Often a guest lecturer and visiting professor throughout the world, Dr. Gelenberg has sat on National Institute of Mental Health committees, is a Distinguished Life Fellow of the APA, former chair of its Committee on Research on Psychiatric Treatments, past President of the West Coast College of Biological Psychiatry, fellow of the American College of Neuropsychopharmacology, and member of the American College of Psychiatrists. He is on the Council of the Central Pennsylvania Psychiatric Society, Boards of Directors of the American Society of Clinical Psychopharmacology and the Pennsylvania Psychiatric Institute, Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service, Scientific Advisory Board of the Depression and Bipolar Support Alliance, and NCDEU Steering Committee. He chairs the Data and Safety Monitoring Board of the NIMH study Treating Depression and Insomnia (TRIAD). Consistently listed in The Best Doctors in America and America's Top Doctors, he received an Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill and two teaching awards at the University of Arizona. He has mentored numerous researchers, many of whom are now highly productive scientists.
A native of Philadelphia, Alan Gelenberg received an A.B. from Columbia University and M.D. from the University of Pennsylvania. After a year's internship in internal medicine at Presbyterian-University of Pennsylvania Medical Center, he was a resident in psychiatry at the Massachusetts General Hospital. For six years he was a commissioned officer in the U.S. Army Reserves. Dr. Gelenberg's wife was the first woman TV news anchor in Arizona, on the air for 34 years, and a candidate for the U.S. Congress. Between them, the Gelenbergs have five children.
If you have a question for Dr. Gelenberg, you can send him an email at firstname.lastname@example.org.