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IN THIS MONTH'S ISSUE:
October 2014

ADHD, Stimulants, and Young Hearts
Stimulant medications, such as methylphenidate (Ritalin and others), are associated with a small increase in the risk of cardiovascular events in children and adolescents, and a slightly greater risk in those with attention-deficit/hyperactivity disorder (ADHD).

Estradiol for Schizophrenia?
In a double-blind, randomized, placebo-controlled trial, women with schizophrenia or schizoaffective disorder had a small but statistically significant improvement in previously treatment-resistant psychotic symptoms when treated with transdermal estradiol.

Rapid Clozapine Titration: Additional Comments
Some patients with schizophrenia may benefit from very gradual (rather than rapid) titration of clozapine (Clozaril and others), especially if they are taking concomitant benzodiazepines.

In Brief
Mindfulness Training Promotes Recovery from Stress in Military Personnel; Compound in Pomegranates May Help Slow Neurodegenerative Disorders

Pregnenolone for Bipolar Depression?
Adjunctive treatment with the neurosteroid pregnenolone may improve depressive symptoms in patients with bipolar disorder.

Allopurinol in Acute Mania?
Preliminary findings indicate benefit from adding allopurinol (Zyloprim and others) to valproate (Depakene and others) for the treatment of acute mania.

About Alan J. Gelenberg, M.D.

Alan J. Gelenberg, M.D. is Shively-Tan Professor and Chair of Psychiatry at Penn State University. He is Editor-in-Chief of the Journal of Clinical Psychiatry, the field's most widely read peer-reviewed journal, and founding author of Biological Therapies in Psychiatry Newsletter. Dr. Gelenberg has been on the faculties of Harvard, Massachusetts General Hospital, M.I.T. and the University of Wisconsin, headed the University of Arizona's Department of Psychiatry, and was President and CEO of Healthcare Technology Systems of Madison, WI.

Dr. Gelenberg has been lead author of manuscripts in the Lancet, New England Journal of Medicine, and Journal of the AMA and has published over 280 scientific articles, editorials, and book chapters. He chaired the American Psychiatric Association's (APA) workgroup on Treatment Guidelines for Major Depressive Disorder, 3rd edition, was on a joint APA/AMA taskforce on similar guidelines for primary care and a committee to advise the U.S. Centers for Disease Control about depression. He helped create the ASEX scale to monitor sexual side effects of antidepressants and electronic versions of suicide-assessment instruments.

Often a guest lecturer and visiting professor throughout the world, Dr. Gelenberg has sat on National Institute of Mental Health committees, is a Distinguished Life Fellow of the APA, former chair of its Committee on Research on Psychiatric Treatments, past President of the West Coast College of Biological Psychiatry, fellow of the American College of Neuropsychopharmacology, and member of the American College of Psychiatrists. He is on the Council of the Central Pennsylvania Psychiatric Society, Boards of Directors of the American Society of Clinical Psychopharmacology and the Pennsylvania Psychiatric Institute, Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service, Scientific Advisory Board of the Depression and Bipolar Support Alliance, and NCDEU Steering Committee. He chairs the Data and Safety Monitoring Board of the NIMH study Treating Depression and Insomnia (TRIAD). Consistently listed in The Best Doctors in America and America's Top Doctors, he received an Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill and two teaching awards at the University of Arizona. He has mentored numerous researchers, many of whom are now highly productive scientists.

A native of Philadelphia, Alan Gelenberg received an A.B. from Columbia University and M.D. from the University of Pennsylvania. After a year's internship in internal medicine at Presbyterian-University of Pennsylvania Medical Center, he was a resident in psychiatry at the Massachusetts General Hospital. For six years he was a commissioned officer in the U.S. Army Reserves. Dr. Gelenberg's wife was the first woman TV news anchor in Arizona, on the air for 34 years, and a candidate for the U.S. Congress. Between them, the Gelenbergs have five children.

If you have a question for Dr. Gelenberg, you can send him an email at drgelenberg@btpnews.com.