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October 2016

Stimulants for ADHD: Tracking Two Adverse Events
For children and adolescents with ADHD, stimulant treatment is associated with an increased risk of cardiovascular events and a decreased risk of anxiety.

Long-Term Effects of Antidepressants on Weight
Bupropion (Wellbutrin and others) may be the most appropriate first-line treatment for depressed patients concerned about long-term weight gain.

Two Antipsychotic Warnings from the FDA
The FDA has issued warnings about a rare but serious skin reaction with olanzapine (Zyprexa and others) and the development of impulse-control problems with aripiprazole (Abilify and others).

Milnacipran and Levomilnacipran
There are few clinically relevant differences between milnacipran (Savella) and its levo enantiomer levomilnacipran (Fetzima).

In Brief
In an Animal Trial, Exercise Increased Production of Brain-Derived Neurotrophic Factor; Exercise Improves Cognitive Function in Patients with Schizophrenia

Anticholinergic Drugs Raise Fracture Risk
Anticholinergic drugs should be avoided in older people for many reasons, including an increased risk of fractures.

About Alan J. Gelenberg, M.D.

Alan J. Gelenberg, M.D. is a Professor Emeritus at the University of Arizona and has chaired Departments of Psychiatry at Arizona and Penn State. He has also been on the faculty of Harvard Medical School, MIT, and the University of Wisconsin. He is Editor-in-Chief of the Journal of Clinical Psychiatry, the field's most widely read peer-reviewed journal, and founding author of Biological Therapies in Psychiatry Newsletter.

Dr. Gelenberg has been lead author of manuscripts in the Lancet, New England Journal of Medicine, and Journal of the AMA and has published over 280 scientific articles, editorials, and book chapters. He chaired the American Psychiatric Association's (APA) workgroup on Treatment Guidelines for Major Depressive Disorder, 3rd edition, was on a joint APA/AMA taskforce on similar guidelines for primary care and a committee to advise the U.S. Centers for Disease Control about depression. He helped create the ASEX scale to monitor sexual side effects of antidepressants and electronic versions of suicide-assessment instruments.

Often a guest lecturer and visiting professor throughout the world, Dr. Gelenberg has sat on National Institute of Mental Health committees, is a Distinguished Life Fellow of the APA, former chair of its Committee on Research on Psychiatric Treatments, past President of the West Coast College of Biological Psychiatry, fellow of the American College of Neuropsychopharmacology, and member of the American College of Psychiatrists. He is on the Council of the Central Pennsylvania Psychiatric Society, Boards of Directors of the American Society of Clinical Psychopharmacology and the Pennsylvania Psychiatric Institute, Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service, Scientific Advisory Board of the Depression and Bipolar Support Alliance, and NCDEU Steering Committee. He chairs the Data and Safety Monitoring Board of the NIMH study Treating Depression and Insomnia (TRIAD). Consistently listed in The Best Doctors in America and America's Top Doctors, he received an Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill and two teaching awards at the University of Arizona. He has mentored numerous researchers, many of whom are now highly productive scientists.

A native of Philadelphia, Alan Gelenberg received an A.B. from Columbia University and M.D. from the University of Pennsylvania. After a year's internship in internal medicine at Presbyterian-University of Pennsylvania Medical Center, he was a resident in psychiatry at the Massachusetts General Hospital. For six years he was a commissioned officer in the U.S. Army Reserves. Dr. Gelenberg's wife was the first woman TV news anchor in Arizona, on the air for 34 years, and a candidate for the U.S. Congress. Between them, the Gelenbergs have five children.

If you have a question for Dr. Gelenberg, you can send him an email at