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IN THIS MONTH'S ISSUE:
April 2015

Antidepressants and the Risk of a Manic Switch in Young Bipolar Patients
Current evidence suggests that antidepressants are associated with a substantially increased risk of precipitating a manic switch in children and adolescents with bipolar disorder.

Start Lithium Early?
Starting lithium early in the course of bipolar disorder appears to improve the probability of an excellent response to lithium.

New-Onset Cardiovascular Disease in Bipolar Disorder Patients
Patients with bipolar I or bipolar II disorder experience cardiovascular disease earlier in their lives and at a higher rate than the general population and than patients with major depressive disorder.

In Brief
Attention-Deficit/Hyperactivity Disorder (ADHD) Is Associated with Increased Mortality; Depressive, Anxiety, and Behavioral Disorders May Be Risk Factors for Bipolar Disorder

Antipsychotics and Mortality in Schizophrenia
Examining a nationwide cohort of patients with schizophrenia, investigators in Finland found that the highest risk of mortality was associated with no antipsychotic treatment, and the next highest risk came from high antipsychotic doses.

Anticholinergic Drugs for Dementia Patients
A majority of nursing home residents with dementia are treated with anticholinergic agents, which may counteract the benefits of acetylcholinesterase inhibitors and directly impair memory and cognition.

About Alan J. Gelenberg, M.D.

Alan J. Gelenberg, M.D. is Shively-Tan Professor and Chair of Psychiatry at Penn State University. He is Editor-in-Chief of the Journal of Clinical Psychiatry, the field's most widely read peer-reviewed journal, and founding author of Biological Therapies in Psychiatry Newsletter. Dr. Gelenberg has been on the faculties of Harvard, Massachusetts General Hospital, M.I.T. and the University of Wisconsin, headed the University of Arizona's Department of Psychiatry, and was President and CEO of Healthcare Technology Systems of Madison, WI.

Dr. Gelenberg has been lead author of manuscripts in the Lancet, New England Journal of Medicine, and Journal of the AMA and has published over 280 scientific articles, editorials, and book chapters. He chaired the American Psychiatric Association's (APA) workgroup on Treatment Guidelines for Major Depressive Disorder, 3rd edition, was on a joint APA/AMA taskforce on similar guidelines for primary care and a committee to advise the U.S. Centers for Disease Control about depression. He helped create the ASEX scale to monitor sexual side effects of antidepressants and electronic versions of suicide-assessment instruments.

Often a guest lecturer and visiting professor throughout the world, Dr. Gelenberg has sat on National Institute of Mental Health committees, is a Distinguished Life Fellow of the APA, former chair of its Committee on Research on Psychiatric Treatments, past President of the West Coast College of Biological Psychiatry, fellow of the American College of Neuropsychopharmacology, and member of the American College of Psychiatrists. He is on the Council of the Central Pennsylvania Psychiatric Society, Boards of Directors of the American Society of Clinical Psychopharmacology and the Pennsylvania Psychiatric Institute, Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service, Scientific Advisory Board of the Depression and Bipolar Support Alliance, and NCDEU Steering Committee. He chairs the Data and Safety Monitoring Board of the NIMH study Treating Depression and Insomnia (TRIAD). Consistently listed in The Best Doctors in America and America's Top Doctors, he received an Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill and two teaching awards at the University of Arizona. He has mentored numerous researchers, many of whom are now highly productive scientists.

A native of Philadelphia, Alan Gelenberg received an A.B. from Columbia University and M.D. from the University of Pennsylvania. After a year's internship in internal medicine at Presbyterian-University of Pennsylvania Medical Center, he was a resident in psychiatry at the Massachusetts General Hospital. For six years he was a commissioned officer in the U.S. Army Reserves. Dr. Gelenberg's wife was the first woman TV news anchor in Arizona, on the air for 34 years, and a candidate for the U.S. Congress. Between them, the Gelenbergs have five children.

If you have a question for Dr. Gelenberg, you can send him an email at drgelenberg@btpnews.com.