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IN THIS MONTH'S ISSUE:
July 2015

Generic Olanzapine: Switching from the Brand Name
Despite being associated with a significant drop in blood drug level, switching from brand name olanzapine to a generic formulation did not decrease clinical stability in one study.

Can Anticholinergics Increase Dementia Risk?
Some evidence suggests that, in elderly patients, anticholinergic medications appear to increase the risk of dementia.

The Mediterranean Diet and Cognition
A growing body of evidence suggests that interventions that support cardiovascular health, such as eating a "Mediterranean" type of diet, can also benefit the brain.

Asenapine (Saphris): Once vs Twice Daily
Taking asenapine once rather than twice a day might help offset daytime sleepiness.

In Brief
Patients with Schizophrenia Who Have High Cholesterol Levels Score Better on Cognitive Tests; Supplementation with Folic Acid and Vitamin B Does Not Reduce Depression Risk in Older Women

Suvorexant (Belsomra)
The new hypnotic drug suvorexant, approved for the treatment of insomnia, appears to be similar to earlier agents in terms of effectiveness and side effects, including next-day problems with motor skills, alertness, and cognition.

About Alan J. Gelenberg, M.D.

Alan J. Gelenberg, M.D. is a Professor Emeritus at the University of Arizona and has chaired Departments of Psychiatry at Arizona and Penn State. He has also been on the faculty of Harvard Medical School, MIT, and the University of Wisconsin. He is Editor-in-Chief of the Journal of Clinical Psychiatry, the field's most widely read peer-reviewed journal, and founding author of Biological Therapies in Psychiatry Newsletter.

Dr. Gelenberg has been lead author of manuscripts in the Lancet, New England Journal of Medicine, and Journal of the AMA and has published over 280 scientific articles, editorials, and book chapters. He chaired the American Psychiatric Association's (APA) workgroup on Treatment Guidelines for Major Depressive Disorder, 3rd edition, was on a joint APA/AMA taskforce on similar guidelines for primary care and a committee to advise the U.S. Centers for Disease Control about depression. He helped create the ASEX scale to monitor sexual side effects of antidepressants and electronic versions of suicide-assessment instruments.

Often a guest lecturer and visiting professor throughout the world, Dr. Gelenberg has sat on National Institute of Mental Health committees, is a Distinguished Life Fellow of the APA, former chair of its Committee on Research on Psychiatric Treatments, past President of the West Coast College of Biological Psychiatry, fellow of the American College of Neuropsychopharmacology, and member of the American College of Psychiatrists. He is on the Council of the Central Pennsylvania Psychiatric Society, Boards of Directors of the American Society of Clinical Psychopharmacology and the Pennsylvania Psychiatric Institute, Professional Advisory Council of the Neuroleptic Malignant Syndrome Information Service, Scientific Advisory Board of the Depression and Bipolar Support Alliance, and NCDEU Steering Committee. He chairs the Data and Safety Monitoring Board of the NIMH study Treating Depression and Insomnia (TRIAD). Consistently listed in The Best Doctors in America and America's Top Doctors, he received an Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill and two teaching awards at the University of Arizona. He has mentored numerous researchers, many of whom are now highly productive scientists.

A native of Philadelphia, Alan Gelenberg received an A.B. from Columbia University and M.D. from the University of Pennsylvania. After a year's internship in internal medicine at Presbyterian-University of Pennsylvania Medical Center, he was a resident in psychiatry at the Massachusetts General Hospital. For six years he was a commissioned officer in the U.S. Army Reserves. Dr. Gelenberg's wife was the first woman TV news anchor in Arizona, on the air for 34 years, and a candidate for the U.S. Congress. Between them, the Gelenbergs have five children.

If you have a question for Dr. Gelenberg, you can send him an email at drgelenberg@btpnews.com.