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November 2015

Brexpiprazole (Rexulti)
The manufacturer of aripiprazole (Abilify and others), which is now off patent, has released a similar drug called brexpiprazole (Rexulti), which the FDA has approved to treat schizophrenia and as an adjunct to antidepressants for major depressive disorder (MDD).

Medical Marijuana
Several recent reviews question the evidence for the efficacy of medical marijuana and caution about its potential long-term side effects.

In Brief
Vitamin D Deficiency Associated with Increased Cognitive Decline in Older Adults; High-Glycemic Diets Associated with Increased Risk of Depression in Postmenopausal Women

Nitrous Oxide for Depression?
A pilot study of nitrous oxide inhalation for patients with treatment-resistant depression has yielded positive results.

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Originating at the Massachusetts General Hospital and Harvard Medical School, Biological Therapies in Psychiatry has been a trusted resource for physicians for over 30 years. Described as "influential" by the Atlantic Monthly, this concise, four-page, monthly newsletter provides up-to-date information about the rapidly expanding field of psychotropic medications and other biological treatments for mental disorders.

From his perspective as an editor, teacher, investigator, and clinician, Alan J. Gelenberg, M.D., reviews the widespread literatures of science and clinical practice. Dr. Gelenberg distills the material most relevant for a busy practitioner and presents it each month with a balance of scientific curiosity, healthy skepticism, and clinical experience.

Dr. Gelenberg is Professor and Interim Chair of Psychiatry at Penn State, Hershey. Since 1987, Dr. Gelenberg has been Editor-in-Chief of the Journal of Clinical Psychiatry, and he recently chaired the workgroup that revised the American Psychiatric Association's major depressive disorder guidelines. Dr. Gelenberg has been on the faculty of Harvard Medical School, MIT, and the University of Arizona and has written numerous scientific articles and book chapters on mood disorders, depression, and schizophrenia. He is listed in the Best Doctors in America and America's Top Doctors and received the 1997 Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill.

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