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IN THIS MONTH'S ISSUE:
September 2016

Antipsychotics, Antidepressants, Torsades de Pointes, and the Risk of Sudden Death
Some antipsychotics and antidepressants may elevate the risk of sudden death by prolonging the QT interval, especially in older patients and those with heart disease.

Pregabalin in Pregnancy
In one study of human exposure during pregnancy, pregabalin (Lyrica) was associated with an increased rate of congenital malformations.

Preventing MDD via the Web
For people with subthreshold depression, web-based, guided self-help strategies may decrease the risk of developing major depressive disorder.

In Brief
Escitalopram (Lexapro) Does Not Improve Clinical Outcome in Patients with Heart Failure and Depression; E-cigarette Use in Adolescents Is Associated with Increased Cigarette Smoking in Transition to Adulthood

Cataract Risk and Antipsychotics
In a nested case-control study, investigators found that neither first- nor second-generation antipsychotics were associated with the development of cataracts in patients with schizophrenia.

Antidepressants and Hyponatremia
Almost all antidepressants are associated with hyponatremia, and older patients are at greater risk.

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Originating at the Massachusetts General Hospital and Harvard Medical School, Biological Therapies in Psychiatry has been a trusted resource for physicians for over 30 years. Described as "influential" by the Atlantic Monthly, this concise, four-page, monthly newsletter provides up-to-date information about the rapidly expanding field of psychotropic medications and other biological treatments for mental disorders.

From his perspective as an editor, teacher, investigator, and clinician, Alan J. Gelenberg, M.D., reviews the widespread literatures of science and clinical practice. Dr. Gelenberg distills the material most relevant for a busy practitioner and presents it each month with a balance of scientific curiosity, healthy skepticism, and clinical experience.

Dr. Gelenberg is Professor and Interim Chair of Psychiatry at Penn State, Hershey. Since 1987, Dr. Gelenberg has been Editor-in-Chief of the Journal of Clinical Psychiatry, and he recently chaired the workgroup that revised the American Psychiatric Association's major depressive disorder guidelines. Dr. Gelenberg has been on the faculty of Harvard Medical School, MIT, and the University of Arizona and has written numerous scientific articles and book chapters on mood disorders, depression, and schizophrenia. He is listed in the Best Doctors in America and America's Top Doctors and received the 1997 Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill.

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