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IN THIS MONTH'S ISSUE:
April 2016

Androgens and Depression
Low serum levels of androgen and estrogen sex steroids might be associated with depression in older men and women.

Metformin for Antipsychotic Weight Gain
A study of South Asian patients provides further evidence for the effectiveness of metformin (Glucophage and others) in combatting antipsychotic-induced weight gain.

Selecting an Antipsychotic for a First Episode of Schizophrenia: Aripiprazole versus Risperidone
Aripiprazole (Abilify and others) is a better choice for a first episode of schizophrenia than risperidone (Risperdal and others) unless akathisia is a concern.

In Brief
Decrease in Cardiovascular Risk Factors Linked to Decline in Rate of Dementia; Coffee and Tea May Have a Dose-Related Protective Effect Against Depression

Transcutaneous VNS
A new study confirms earlier findings that transcutaneous vagus nerve stimulation (tVNS) produces statistically greater reductions in depression than sham stimulation.

Bipolar Maintenance Treatments: Comparing Monotherapies
In a study of maintenance treatments for patients with bipolar disorder, lithium showed greater efficacy than valproate (Depakene and others), olanzapine (Zyprexa and others), and quetiapine (Seroquel and others).

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Originating at the Massachusetts General Hospital and Harvard Medical School, Biological Therapies in Psychiatry has been a trusted resource for physicians for over 30 years. Described as "influential" by the Atlantic Monthly, this concise, four-page, monthly newsletter provides up-to-date information about the rapidly expanding field of psychotropic medications and other biological treatments for mental disorders.

From his perspective as an editor, teacher, investigator, and clinician, Alan J. Gelenberg, M.D., reviews the widespread literatures of science and clinical practice. Dr. Gelenberg distills the material most relevant for a busy practitioner and presents it each month with a balance of scientific curiosity, healthy skepticism, and clinical experience.

Dr. Gelenberg is Professor and Interim Chair of Psychiatry at Penn State, Hershey. Since 1987, Dr. Gelenberg has been Editor-in-Chief of the Journal of Clinical Psychiatry, and he recently chaired the workgroup that revised the American Psychiatric Association's major depressive disorder guidelines. Dr. Gelenberg has been on the faculty of Harvard Medical School, MIT, and the University of Arizona and has written numerous scientific articles and book chapters on mood disorders, depression, and schizophrenia. He is listed in the Best Doctors in America and America's Top Doctors and received the 1997 Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill.

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