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October 2016

Stimulants for ADHD: Tracking Two Adverse Events
For children and adolescents with ADHD, stimulant treatment is associated with an increased risk of cardiovascular events and a decreased risk of anxiety.

Long-Term Effects of Antidepressants on Weight
Bupropion (Wellbutrin and others) may be the most appropriate first-line treatment for depressed patients concerned about long-term weight gain.

Two Antipsychotic Warnings from the FDA
The FDA has issued warnings about a rare but serious skin reaction with olanzapine (Zyprexa and others) and the development of impulse-control problems with aripiprazole (Abilify and others).

Milnacipran and Levomilnacipran
There are few clinically relevant differences between milnacipran (Savella) and its levo enantiomer levomilnacipran (Fetzima).

In Brief
In an Animal Trial, Exercise Increased Production of Brain-Derived Neurotrophic Factor; Exercise Improves Cognitive Function in Patients with Schizophrenia

Anticholinergic Drugs Raise Fracture Risk
Anticholinergic drugs should be avoided in older people for many reasons, including an increased risk of fractures.

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Dr. Gelenberg is Professor and Interim Chair of Psychiatry at Penn State, Hershey. Since 1987, Dr. Gelenberg has been Editor-in-Chief of the Journal of Clinical Psychiatry, and he recently chaired the workgroup that revised the American Psychiatric Association's major depressive disorder guidelines. Dr. Gelenberg has been on the faculty of Harvard Medical School, MIT, and the University of Arizona and has written numerous scientific articles and book chapters on mood disorders, depression, and schizophrenia. He is listed in the Best Doctors in America and America's Top Doctors and received the 1997 Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill.

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