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IN THIS MONTH'S ISSUE:
July 2015

Generic Olanzapine: Switching from the Brand Name
Despite being associated with a significant drop in blood drug level, switching from brand name olanzapine to a generic formulation did not decrease clinical stability in one study.

Can Anticholinergics Increase Dementia Risk?
Some evidence suggests that, in elderly patients, anticholinergic medications appear to increase the risk of dementia.

The Mediterranean Diet and Cognition
A growing body of evidence suggests that interventions that support cardiovascular health, such as eating a "Mediterranean" type of diet, can also benefit the brain.

Asenapine (Saphris): Once vs Twice Daily
Taking asenapine once rather than twice a day might help offset daytime sleepiness.

In Brief
Patients with Schizophrenia Who Have High Cholesterol Levels Score Better on Cognitive Tests; Supplementation with Folic Acid and Vitamin B Does Not Reduce Depression Risk in Older Women

Suvorexant (Belsomra)
The new hypnotic drug suvorexant, approved for the treatment of insomnia, appears to be similar to earlier agents in terms of effectiveness and side effects, including next-day problems with motor skills, alertness, and cognition.

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Originating at the Massachusetts General Hospital and Harvard Medical School, Biological Therapies in Psychiatry has been a trusted resource for physicians for over 30 years. Described as "influential" by the Atlantic Monthly, this concise, four-page, monthly newsletter provides up-to-date information about the rapidly expanding field of psychotropic medications and other biological treatments for mental disorders.

From his perspective as an editor, teacher, investigator, and clinician, Alan J. Gelenberg, M.D., reviews the widespread literatures of science and clinical practice. Dr. Gelenberg distills the material most relevant for a busy practitioner and presents it each month with a balance of scientific curiosity, healthy skepticism, and clinical experience.

Dr. Gelenberg is Professor and Interim Chair of Psychiatry at Penn State, Hershey. Since 1987, Dr. Gelenberg has been Editor-in-Chief of the Journal of Clinical Psychiatry, and he recently chaired the workgroup that revised the American Psychiatric Association's major depressive disorder guidelines. Dr. Gelenberg has been on the faculty of Harvard Medical School, MIT, and the University of Arizona and has written numerous scientific articles and book chapters on mood disorders, depression, and schizophrenia. He is listed in the Best Doctors in America and America's Top Doctors and received the 1997 Exemplary Psychiatrist Award of the National Alliance for the Mentally Ill.

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